🤖 A New Open-Source AI Model for Math Theorems

🐳A New Open-Source AI Model for Math Theorems

🧠AI Reveals Hidden Cause of Alzheimer’s

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Formal Proofs are very strict, rigorous, and meticulously detailed mathematical arguments rooted in the basic building blocks of math.

Lean 4 is a programming language specifically designed to write and verify Formal Proofs.

“DeepSeek-Prover-V2-671B” was trained on 869,659 high school, undergraduate, and graduate math problems from exams, exercises, and competitions.

It relies on Reinforcement Learning from Proof Assistant Feedback (RLPAF), which examines if every single step generated to solve a math problem is absolutely correct according to the rules of math.

It also employs Monte Carlo Tree Search (MCTS) to intelligently simulate a tree of multiple potential solutions to a math problem.

“DeepSeek-Prover-V2-671B” boasts 671 billion parameters, giving it the capacity to store and access more mathematical knowledge to learn, adapt, and solve more complex math problems.

It achieved 88.9% accuracy on the miniF2F benchmark, which consists of 488 math problems drawn from the American Mathematics Competitions (AMC), the International Mathematical Olympiad (IMO), and the American Invitational Mathematics Examination (AIME).

They discovered that PhosphoGlycerate DeHydrogenase (PHGDH), an enzyme that helps our bodies make serine, a building block for proteins, can disrupt how cells in our brain turn genes on and off.

This disruption can interfere with Autophagy, the cellular process of removing damaged proteins from our brain. Imagine tiny garbage collectors that remove old garbage to reduce clutter.

“We hit a wall,” said Sheng Zhong, a Professor in the Shu Chien Lay Department of Bioengineering at UCSD. He understood that PHGDH contributed to Alzheimer’s, but he didn’t know the exact biological process of how it did.

They leveraged AI to generate a three-dimensional (3D) layout of PHGDH, discovering that the enzyme binds to and activates a type of protein called ATF4, which causes disruptions.

They also identified a small molecule called NCT-503 that could potentially be taken as a pill to prevent these disruptions before they occur.

Globally, over 55 million people are living with dementia, with Alzheimer’s contributing to 70% of cases. The incidence of dementia is increasing rapidly, with a new case developing every 3 seconds worldwide.

Around 80% of pharmaceutical professionals used AI in drug discovery at the start of 2024. AI advancements are accelerating the development of new therapeutic solutions for Alzheimer’s.

Structify raises a $4.1M Seed Round to convert unstructured web data into enterprise-ready datasets.

Supio secures a $60M Series B to turn case documents into critical insights for plaintiff firms.

Cast AI closes a $108M Series C to automatically run applications more cost-effectively.

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