🤖 The First Prototype of Mysterious AI Hardware

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In today’s Daily Report:

• 📦The First Prototype of Mysterious AI Hardware

• 🪡AI Finds the Genetic Needle in the Human Haystack

• 🛠Trending Tools

• 🥪Brief Bites

• 💰Funding Frontlines

• 💼Who’s Hiring?

Read Time: 3 minutes

🗞RECENT NEWS

OPENAI

📦The First Prototype of Mysterious AI Hardware

After initially facing design flaws, legal threats, and technical issues, OpenAI finally has a prototype of their secretive AI-powered gadget.

Key Details:

• Earlier this year, OpenAI acquired io Products, Inc. for nearly $6.5 billion, gaining legendary Apple designer Jony Ive and his hand-picked team of 55 designers, architects, and engineers.

• OpenAI CEO Sam Altman explained: “When people see it, they say, ‘That’s it?… It’s so simple.’” Little is known about the secretive AI-powered gadget, though it’s rumored to be screenless and palm-sized to promote less socially disruptive experiences.

• iyO also recently sued OpenAI, alleging they met with them to discuss their in-ear technology, even demoing the “iyO One”: earbuds designed to be the world’s first audio computer. This lawsuit forced OpenAI to disclose that the secretive AI-powered gadget relies solely on audio and visual cues.

Why It’s Important:

• For the past two decades, our digital lives have been dominated by typing, tapping, and touching. Now, the hands-free era is emerging, where technology is built around voice controls and touchless navigation.

• So, what changed?! Not only did speech recognition stop being terrible, but LLMs made talking to technology feel realistic. For example, ChatGPT’s Advanced Voice Mode actually feels like you’re interacting with a real human.

AI RESEARCH

🪡AI Finds the Genetic Needle in the Human Haystack

Harvard Medical School (HMS) recently developed “PopEVE,” an AI-powered diagnostic tool that helps identify genetic mutations most likely to cause severe disease.

Key Details:

• Our DNA contains sequences of billions of “letters,” which tell our body how to grow and heal. These sequences are a specific order of the four Nucleotides: Adenine {A}, Thymine {T}, Cytosine {C}, and Guanine {G}.

• For example, a small piece of DNA might look like this: {ATCGTACG}. The order of these “letters” matters a lot. Even a minor change can affect how our body functions. Only about 2% of our DNA actually contains genes that tell our body how to build tissues and fight infections.

• Every human has tens of thousands of tiny genetic alterations in that 2% of DNA, also known as variants, that affect how we respond to illness. “PopEVE” sorts through these variants and identifies those most likely to cause disease, helping distinguish between common genetic alterations and rare genetic conditions that cause serious health problems.

Why It’s Important:

• When tested on a cohort of around 30,000 patients with severe developmental disorders who hadn’t received a diagnosis, “PopEVE” uncovered previously unidentified variants in about one-third of cases.

• 400 million people worldwide are affected by rare genetic diseases, representing about 5.9% of the global population. More specifically, around 80% of rare diseases have a genetic cause.

THE STOCK MARKET

📍AI Tier Tracker

🔔CLOSING BELL: As of 11/27/2025 market close.

💡STOCK SPOTLIGHT: Each tier showcases a new stock every day.

🛠TRENDING TOOLS

🤘Kadabra turns plain English into automations.

👥Taplio grows your personal brand on LinkedIn.

🎤MusicAI.ai turns lyrics into royalty-free music.

🪧Anymark designs handcrafted logos, instantly.

👷Jotlin turns messy ideas into structured specs.

🧰 Browse our Always Up-To-Date AI Toolkit.

🥪BRIEF BITES

OpenAI Founding Member Andrej Karpathy just urged educators to teach students how to use AI effectively instead of trying to detect AI-written essays.

OpenAI projects that 220 million people will pay for Plus, Pro, and Business ChatGPT plans by 2030, making it the world’s largest subscription business.

Google launched “Learn Everything,” which turns photos of a plant, a burger, or a coffee cup into interactive lessons on any topic with virtual metaphors.

Perplexity AI rolled out “Virtual Try-On,” which allows you to upload selfies and create a photorealistic digital avatar of yourself that virtually tries on clothes.

💰FUNDING FRONTLINES

• AI One landed a $7M Series A to activate the context of your enterprise.

• Tailor raised a $37M Series A to handle all the backend business stuff.

• xAI to close a $15B Series E to advance our knowledge of the universe.

💼WHO’S HIRING?

• Skydio (San Mateo, CA): Cloud Software Engineer Intern, Summer 2026

• Cohere (Remote): AI Data Trainer, English Language, Entry-Level

• Databricks (Mountain View, CA): Product Operation Analyst, Mid-Level

• Hive (San Francisco, CA): Sr. Backend Software Engineer, Senior-Level

📒FINAL NOTE

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